叶酸补充与月经周期短呈负相关

作者: Heidi T, et al.

译者：淄博市临淄区人民医院谢玉翠

摘要：目的：为了评估补充叶酸（单纯叶酸或者含有叶酸的多种维生素）和月经周期特征的关联。这项调查数据来自2007-2011年丹麦互联网登记的5386名备孕女性，年龄跨度18-40岁。

方法：在一项横断面研究中，我们用逻辑回归估计优势比（ORs）,用95%的可信区间来评估叶酸补充与月经周期规律、周期长度，经期和经量的关联。其中，周期长度细化为短周期（<27天），长周期（30-33天），和超长周期（≥34天）。

结果：以未补充叶酸的备孕女性作为对照，和月经周期长度27-29天女性相比，月经短周期的叶酸补充者呈现降低的几率（OR=0.80, 95% 可信区间: 0.68–0.94），长周期女性呈现上升的趋势（OR=1.21, 95% CI: 0.87–1.68）。这种负相关在年龄18-30岁之间（OR=0.68, 95% CI: 0.53–0.87）、未产妇（OR=0.66, 95%CI: 0.52–0.84）、和同时服用单纯叶酸和复合维生素之间的患者（OR=0.75, 95% CI:0.60–0.95）更为明显。我们发现补充叶酸和月经周期的规律性、经期和经量没有明确的关联。

推论：叶酸补充和月经短周期的长度呈负相关。这种负相关在年龄18-30岁之间、未产妇、和同时服用单 纯叶酸和复合维生素之间的女性表现的更为明显。

附原文：Abstract Purpose Toexamine the association between folic acid (FA) supplementation obtainedthrough either single FA tablets or multivitamins (MVs) and menstrual cyclecharacteristics among 5,386 women aged 18–40 years, enrolled in anInternet-based study of Danish women attempting pregnancy during 2007–2011. Methods In a cross-sectional study, weused logistic regression to estimate odds ratios (ORs) and 95% confidenceintervals (CIs) for the associations of FA supplementation with menstrualcycle regularity, short (<27 days), long (30–33 days), and verylong (≥34 days) cycle length, and duration and intensity of menstrual bleeding Results Compared with non-use, FAsupplementation was associated with reduced odds of short cycle length[OR=0.80, 95% CI: 0.68–0.94], and a trend towards increased odds of very longcycle length [OR=1.21, 95% CI: 0.87–1.68] compared with cycle length of 27–29days. The inverse association with short cycle length was stronger among 18–30year-old women [OR=0.68, 95% CI: 0.53–0.87], nulliparous women [OR=0.66, 95%CI: 0.52–0.84], and women who used both FA and MVs [OR=0.75, 95% CI:0.60–0.95]. We found no clear association between FAsupplementation and cycle regularity and duration and intensity of menstrualbleeding.  Conclusion FA supplementation was inversely associated with shortmenstrual cycle length. This association was strongest among women aged 18–30years, nulliparous women, and women who used both FA and MVs. 

引自：Heidi T, Anders H. Riis,Elizabeth E. Hatch, Et al.Folic acid supplement use and menstrual cyclecharacteristics: a cross-sectional study of Danish pregnancy planners. AnnEpidemiol. 2015 OCT, 25(10): 723-729